This worked for me:
I = imread('peppers.png');      %# Load a sample image
imshow(I);                      %# Display it
[r,c,d] = size(I);              %# Get the image size
set(gca,'Units','normalized','Position',[0 0 1 1]);  %# Modify axes size
set(gcf,'Units','pixels','Position',[200 200 c r]);  %# Modify figure size
hold on;
plot(100,100,'r*');             %# Plot something over the image
f = getframe(gcf);              %# Capture the current window
imwrite(f.cdata,'image2.jpg');  %# Save the frame data